4-Formylbenzoic acid → Tert-butyl 4-(4-formylbenzoyl)piperazine-1-carboxylate

HRID 592064Notes

Reaction equation

HRID 592064 reaction equation
[CH:1]([C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=O)=[CH:5][CH:4]=1)=[O:2].[N:12]1([C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1>>[CH:1]([C:3]1[CH:4]=[CH:5][C:6]([C:7]([N:15]2[CH2:14][CH2:13][N:12]([C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])[CH2:17][CH2:16]2)=[O:9])=[CH:10][CH:11]=1)=[O:2]

Participants

3

Reactant 2

HCID 120884-Formylbenzoic acidHCID 143452tert-Butyl piperazine-1-carboxylate

Product 1

HCID 59218188Tert-butyl 4-(4-formylbenzoyl)piperazine-1-carboxylateYield 86.6%

Procedure

In an analogous manner to 21, 4-formylbenzoic acid (600 mg, 3.99 mmol) was reacted with tert-butyl piperazine-1-carboxylate (818.8 mg, 4.40 mmol) to afford desired product as off-white solid (1.1 g, 86.6%).

Sources & evidence

ORD record
ord-6d5453a2a9af4cc3a81dcfecd514ba5a
Source dataset
uspto-grants-2016_01
Patent number
US09238656B2

Reaction notes

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