HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 4-(4-(2-Hydroxypropyl)piperazine-1-carbonyl)benzaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Tert-butyl 4-(4-formylbenzoyl)piperazine-1-carboxylate | HCID 59218188 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 4-(4-(2-Hydroxypropyl)piperazine-1-carbonyl)benzaldehyde | HCID 89726008 | 31.4% |
Reaction Steps
In an analagous manner to 23, tert-butyl 4-(4-formylbenzoyl)piperazine-1-carboxylate 26 (500 mg, 1.57 mmol) in DCM (10 mL) was reacted with TFA (1.17 mL, 15.72 mmol) to afford product as white sticky solid. Yield: 31.4%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09238656B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-2148884d8d50476f82b47dee12198201 |
| Source note | uspto-grants-2016_01 |