4-Formylbenzoic acid → HCID 11514073, compound

HRID 592069Notes

Reaction equation

HRID 592069 reaction equation
[CH:1]([C:3]1[CH:11]=[CH:10][C:6]([C:7]([OH:9])=O)=[CH:5][CH:4]=1)=[O:2].[CH3:12][O:13][C:14](=[O:17])[CH2:15][NH2:16]>>[CH:1]([C:3]1[CH:4]=[CH:5][C:6]([C:7]([NH:16][CH2:15][C:14]([O:13][CH3:12])=[O:17])=[O:9])=[CH:10][CH:11]=1)=[O:2]

Participants

3

Reactant 2

HCID 120884-Formylbenzoic acidHCID 69221Glycine methyl ester

Product 1

HCID 11514073HCID 11514073, compoundYield 81.5%

Procedure

In an analogous manner to 35, 4-formyl benzoic acid 24 (1.0 g, 6.66 mmol) was reacted with glycine methyl ester (653 mg, 7.33 mmol) to give 1.2 gm (81%) of methyl 2-(4-formylbenzamido)acetate 37 as an off-white solid (81%).

Sources & evidence

ORD record
ord-22dc27c458074a7a877d02ad9242b768
Source dataset
uspto-grants-2016_01
Patent number
US09238656B2

Reaction notes

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