HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 592077Generated: November 2, 2026
Propylene Oxide → 3-(2-(4-(2-Hydroxypropyl)piperazin-1-yl)-2-oxoethoxy)benzaldehyde
https://huagongshe.com/reaction/592077
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Propylene Oxide | HCID 6378 | — |
| Reactant | 3-(2-Oxo-2-(piperazin-1-yl)ethoxy)benzaldehyde | HCID 89726202 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 3-(2-(4-(2-Hydroxypropyl)piperazin-1-yl)-2-oxoethoxy)benzaldehyde | HCID 89725870 | 50% |
Reaction Steps
3-(2-oxo-2-(piperazin-1-yl)ethoxy)benzaldehyde (50) (1 eq) was taken in MeOH to which propylene oxide (4 eq) was added and the reaction mixture was heated in a sealed tube at 70° C. for 16 h when LCMS showed completion of reaction. The reaction mixture was concentrated and purified by column chromatography using silica gel (100-200 mesh) to afford the pure product (50%) as a colorless oil. LCMS: 96.31% (M++1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09238656B2 |
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| Source dataset | uspto-grants-2016_01 |
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| ORD ID | ord-ac2aaff236294d37a7f9809d5ac554c0 |
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| Source note | uspto-grants-2016_01 |
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