HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic acid, 2-(4-formylphenoxy)- → Tert-Butyl 4-(2-(4-formylphenoxy)acetyl)piperazine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic acid, 2-(4-formylphenoxy)- | HCID 89177 | — |
| Reactant | Tert-Butyl 4-(2-(3-formylphenoxy)acetyl)piperazine-1-carboxylate | HCID 89725867 | — |
| Product | Tert-Butyl 4-(2-(4-formylphenoxy)acetyl)piperazine-1-carboxylate | HCID 89738600 | 74% |
Reaction Steps
2-(4-Formylphenoxy)acetic acid (53) was treated in an analogous manner to Compound 49 to afford the desired product (74%) as a white solid. NMR: δ 1.461 (s, 9H), 3.38-3.64 (m, 8H), 4.802 (s, 2H), 2.06 (d, J=8.4 Hz, 2H), 7.85 (d, J=8.8 Hz, 2H), 9.899 (s, 1H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09238656B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-bcf30bc8be2549c2a891e2da2f04b088 |
| Source note | uspto-grants-2016_01 |