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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 592083Generated: October 30, 2026

N-Methylpiperidine → 3-(2-(4-Methylpiperazin-1-yl)-2-oxoethoxy)benzaldehyde

https://huagongshe.com/reaction/592083

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN-MethylpiperidineHCID 12291—
Reactant2-(3-Formylphenoxy)acetic acidHCID 601895—
ReactantTert-Butyl 4-(2-(3-formylphenoxy)acetyl)piperazine-1-carboxylateHCID 89725867—
Product3-(2-(4-Methylpiperazin-1-yl)-2-oxoethoxy)benzaldehydeHCID 2837949957%

Reaction Steps

2-(3-Formylphenoxy)acetic acid (48) was treated with 1-methylpiperidine in an analogous manner to Compound 49 to afford the desired product (57%) as a colorless oil. LCMS: 99.0% (M++1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09238656B2
Source datasetuspto-grants-2016_01
ORD IDord-4c6068a07dd14ea09da3de5267862156
Source noteuspto-grants-2016_01