HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-Methylpiperidine → 4-(2-(4-Methylpiperazin-1-yl)-2-oxoethoxy)benzaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-Methylpiperidine | HCID 12291 | — |
| Reactant | Acetic acid, 2-(4-formylphenoxy)- | HCID 89177 | — |
| Reactant | Tert-Butyl 4-(2-(3-formylphenoxy)acetyl)piperazine-1-carboxylate | HCID 89725867 | — |
| Product | 4-(2-(4-Methylpiperazin-1-yl)-2-oxoethoxy)benzaldehyde | HCID 28379493 | 66% |
Reaction Steps
2-(4-Formylphenoxy)acetic acid (53) was treated with 1-methylpiperidine in an analogous manner to Compound 49 to afford the desired product (66%) as a colorless oil. LCMS: 99.0% (M++1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09238656B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-faedc26ebb2d4a61a725f1b1aaa7de48 |
| Source note | uspto-grants-2016_01 |