4-(2-(4-Methylpiperazin-1-yl)-2-oxoethoxy)benzaldehyde → HCID 178481077, compound

Participants

Reaction Steps

(1S,2S,3R,4R)-3-(2,3-Diamino-5-chloro-pyridin-4-ylamino)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid amide (1 eq.) and 4-(2-(4-methylpiperazin-1-yl)-2-oxoethoxy)benzaldehyde (58) (1.1 eq) were reacted in an analogous manner as compound CCXXIII to yield the desired product (26%) as an off white solid. NMR: δ (1H, 400 MHz, DMSO-d6): 1.38 (1H, d, J=8 Hz), 2.19 (3H, s), 2.20-2.35 (5H, m), 2.62 (1H, d, J=8.4 Hz), 2.78 (1H, s), 2.89 (1H, s), 3.40-3.50 (4H, m), 4.91 (2H, s), 5.16 (1H, t, J=8 Hz), 6.36-6.40 (2H, m), 7.08 (2H, d, J=8.4 Hz), 7.11-7.14 (1H, m), 7.22 (1H, bs), 7.76 (1H, bs), 7.92 (1H, s), 8.05 (2H, d, J=8.4 Hz).

Provenance & Evidence