Acetic acid, 2-(4-formylphenoxy)- → HCID 178514004, compound

Participants

Reaction Steps

(1S,2S,3R,4R)-3-(2,3-Diamino-5-chloro-pyridin-4-ylamino)-bicyclo[2.2.1]hept-5-ene-2-carboxylic acid amide (1 eq.) and 2-(4-Formylphenoxy)acetic acid (53) (1.1 eq) were reacted in an analogous manner as compound CCXXIII to yield the desired product (29%) as a white solid. NMR: δ (1H, 400 MHz, DMSO-d6): 1.37 (1H, d, J=8.4 Hz), 2.23 (1H, d, J=8.4 Hz), 2.62 (1H, d, J=7.6 Hz), 2.77 (1H, s), 2.88 (1H, s), 4.31 (2H, bs), 5.20 (1H, t, J=8.8 Hz), 6.34-6.41 (2H, m), 6.77 (1H, d, J=8.8 Hz), 6.95 (2H, d, J=8 Hz), 7.07 (1H, d, J=8.8 Hz), 7.20-7.25 (1H, m), 7.75 (1H, bs), 7.90 (1H, s), 8.02 (2H, d, J=8.0 Hz).

Provenance & Evidence