Methanol → HCID 89725996, compound

Participants

Reaction Conditions

Reaction Steps

3-(1-(2,2,2-trifluoroacetyl)piperidin-4-yloxy)benzaldehyde (62) (1 eq) was taken in MeOH to which propylene oxide (4 eq) was added and the reaction mixture was heated in a sealed tube at 70° C. for 8 h when LCMS showed completion of reaction. The reaction mixture was concentrated and purified by column chromatography using silica gel (100-200 mesh) to afford the pure product as a colorless oil.

Provenance & Evidence