Phenol → (1,1'-Biphenyl)-2,3'-diol

Participants

Reaction Conditions

Reaction Steps

The preparation of tagged diphenol 2.4 (3,3-bis(4-hydroxyphenyl)butyl 2-oxo-2H-chromene-3-carboxylate). Phenol (200 mmol) and a catalyst (e.g., Cs2.5H0.25DEAT0.25PW12O40, 0.5 g) can be combined under nitrogen in a 250 mL three necked flask equipped with a condenser and a magnetic stirrer and heated to 80° C. with stirring. A tagged ketone (20 mmol), such as 2-oxo-2H-chromene-3-carboxylic acid 3-oxo-butyl ester, can be added and diphenol 2.4 can be produced with high (e.g., approximately 96%) selectivity for the p,p-isomer.

Provenance & Evidence