2-Amino-6-methoxybenzothiazole → HCID 46927440, compound

Participants

Reaction Steps

To a mixture of 2-(4-(pyridin-4-yl)phenyl)acetic acid 3-1 (45 mg, 0.21 mmol), 6-methoxybenzo[d]thiazol-2-amine 3-2 (36 mg, 0.20 mmol), and DIEA (32 mg, 0.25 mmol) in DMF (0.5 mL) under stiffing was added HATU (84 mg, 0.22 mmol). The solution was stirred for 2 hours before it was subject to reverse phase HPLC for purification to give compound 3 as white solid. MS m/z 376.1 (M+1); 1H NMR 400 MHz (DMSO-d6) δ 12.60(s, 1H), 8.70(m, 2H), 7.87(m, 2H), 7.78(m, 2H), 7.72(d, 1H, J=8.8 Hz), 7.63(d, 1H, J=2.8 Hz), 7.58(m, 2H), 7.11(dd, 1H, J1=8.8 Hz, J2=2.4 Hz), 3.96(s, 2H), 3.86(s, 3H).

Provenance & Evidence