HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 58447813, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | 2-(6-Chloropyridin-3-yl)acetic acid | HCID 14071571 | — |
| Reactant | 5-(3-Fluorophenyl)pyridin-2-amine | HCID 20099807 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 58447813 | HCID 58447813 | — |
Reaction Steps
A mixture of 2-(6-chloropyridin-3-yl)acetic acid (521 mg, 3.03 mmol), 5-(3-fluorophenyl)pyridin-2-amine (570 mg, 3.03 mmol), HATU (1250 mg, 3.29 mmol) and DIEA (784 μl, 4.50 mmol) in DMF (10 ml) was stirred at room temperature overnight. DMF was mostly removed by evaporation under reduced pressure. The residue was dissolved in EtOAc (50 ml), washed with 3% Na2CO3 solution (30 ml) and water (50 mL), and dried over Na2SO4. After concentration by evaporation, the residue was subjected to silica gel column chromatography to give 2-(6-chloropyridin-3-yl)-N-(5-(3-fluorophenyl)pyridin-2-yl)acetamide 140-1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09238646B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-3749997198ba42839a2423119b0a6602 |
| Source note | uspto-grants-2016_01 |