HCID 58447716, compound → 6-(3-Fluorophenyl)pyridin-3-amine

HRID 592250Notes

Reaction equation

HRID 592250 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([C:8]2[CH:13]=[CH:12][C:11]([N+:14]([O-])=O)=[CH:10][N:9]=2)[CH:5]=[CH:6][CH:7]=1.[H][H]>[Pd].CO>[F:1][C:2]1[CH:3]=[C:4]([C:8]2[N:9]=[CH:10][C:11]([NH2:14])=[CH:12][CH:13]=2)[CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 2

HCID 58447716HCID 58447716, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 463118956-(3-Fluorophenyl)pyridin-3-amine

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

To a round-bottom flask was added 2-(3-fluorophenyl)-5-nitropyridine (3.8 g, 17 mmol), Pd/C (0.5 g) and methanol (100 mL). The reaction was stirred for 4 hours under hydrogen atmosphere by attaching a hydrogen balloon. The reaction was flushed with nitrogen and the solid was removed by filtration. The solvent was removed by rotary evaporation to give 6-(3-fluorophenyl)pyridin-3-amine 219-1 as brown solid. MS m/z 189.1 (M+1).

Workup

  1. customThe reaction was flushed with nitrogen
  2. customthe solid was removed by filtration
  3. customThe solvent was removed by rotary evaporation

Sources & evidence

ORD record
ord-d4a6464532694780ae8b79f19d2050bb
Source dataset
uspto-grants-2016_01
Patent number
US09238646B2

Reaction notes

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