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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 592269Generated: October 30, 2026

Hydrochloric Acid → HCID 66661229, compound

https://huagongshe.com/reaction/592269

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
ReactantHCID 86646747HCID 86646747—
Solvent1,4-DioxaneHCID 31275—
ProductHCID 66661229HCID 66661229106.4%

Reaction Steps

To a solution of tert-butyl {(1R)-1-[1-oxido-6-(trifluoromethyl)-3-pyridinyl]ethyl}carbamate (140 mg, 0.457 mmol) in dioxane (2 mL) was added hydrogen chloride (4.0 M in dioxane; 0.343 mL, 1.371 mmol). The reaction mixture was stirred for 4 h. The reaction mixture was concentrated to dryness to give the hydrochloride salt of the title compound (118 mg). MS 207.1 (M+1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09238647B2
Source datasetuspto-grants-2016_01
ORD IDord-f5e3fb45d30b48d18140e45325098c7e
Source noteuspto-grants-2016_01