tert-Butylsulfinamide, (R)-(+)- → (NZ)-2-methyl-N-[[2-(trifluoromethyl)pyrimidin-5-yl]methylidene]propane-2-sulfinamide

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-(trifluoromethyl)pyrimidine-5-carbaldehyde (27.2 g, 99 mmol) in dichloroethane (250 mL) was added (R)-(+)-2-methyl-2-propanesulfinamide (13.3 g, 109.0 mmol) and copper(II) sulfate (31.5 g, 197.0 mmol). The mixture was heated to 50° C. After 18 h, the mixture was cooled to ambient temperature and filtered through a pad of silica gel. The filtered cake was washed with dichloromethane and the filtrate was concentrated to give the title compound (27.3 g). MS 224 [(M+1)-56].

Provenance & Evidence