反应详情

温度

85 °C

Trimethyl orthoformate (100 mL, 903 mmol) was added neat to tert-butyl 2-chloro-6-hydrazinoisonicotinate (10.0 g, 41.0 mmol). The mixture was heated to 85° C. After 5 h, the mixture was cooled to ambient temperature and concentrated. Purification by silica gel chromatography (100% hexanes→50% hexanes/ethyl acetate) gave the title compound (4.55 g): LC-MS [M+1]=254.1.

1. temperaturethe mixture was cooled to ambient temperature
2. concentrationconcentrated
3. customPurification by silica gel chromatography (100% hexanes→50% hexanes/ethyl acetate)