Isobutyric Acid → HCID 66690890, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (1R)-1-(3-methyl-1,2,4-oxadiazol-5-yl)ethyl 6-amino-4′-fluoro-5-hydroxybiphenyl-3-carboxylate (10.0 mg, 28.0 μmol), and isobutyric acid (4.94 mg, 56.0 μmol) and solid support triphenylphosphine (75% by weight; 29.4 mg, 84.0 μmol) in acetonitrile (0.28 mL) was added trichloroacetonitrile (5.63 μL, 56.0 μmol). The mixture was heated in a microwave reactor for 10 min at 150° C. The mixture was cooled to ambient temperature, filtered and concentrated. Purification by reverse phase HPLC (C-18, 95% water/acetonitrile→5% water/acetonitrile with 0.05% ammonium hydroxide) gave the title compound (3.3 mg). HRMS [M+1] found=409.1683.

Provenance & Evidence