反应详情

A solution of 2-chloro-6-fluorobenzonitrile (8.0 g, 51.61 mmol) in conc. sulphuric acid (50 mL) was heated at 60-70° C. for 6-7 h. The reaction mass was quenched in water and extracted with DCM. The organic layer was dried over anhydrous sodium sulphate and concentrated to afford 5.5 g of desired product.

1. customThe reaction mass was quenched in water
2. extractionextracted with DCM
3. dry with materialThe organic layer was dried over anhydrous sodium sulphate
4. concentrationconcentrated