HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → 2-Chloro-6-fluorobenzoyl isocyanate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 2-Chloro-6-fluorobenzamide | HCID 98564 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Product | 2-Chloro-6-fluorobenzoyl isocyanate | HCID 13051731 | 91,106.602% |
Reaction Steps
To a solution of 2-chloro-6-fluorobenzamide (2.0 g, 0.011 mmol) in EDC (10 mL) was added oxalyl chloride (2.18 g, 0.017 mmol). The reaction mass was refluxed for 24 h. Excess of solvent was removed under vacuum to afford 2.0 g of desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09439890B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-4548ea085f674a4d899d467001b5b831 |
| Source note | uspto-grants-2016_09 |