反应详情

温度

40 °C

A solution of tert-butyl 4-(4-((4-(2-(1-(methoxycarbonyl)cyclopropyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate (A4) (0.304 g, 0.487 mmol) and LiOH.H2O (204 mg, 4.87 mmol) in THF (7 mL), MeOH (7 mL) and H2O (1.5 mL) was stirred at room temperature overnight. The resulting mixture was then heated to 40° C. and stirred for 3.5 days. The volatiles were removed under reduced pressure and the residue was taken up in EtOAc (50 mL). Aqueous HCl (2 M, 50 mL) was added cautiously and the layers were separated. The aqueous phase was extracted with EtOAc (2×50 mL), and then the combined organics were washed with brine and dried over MgSO4. The solvent was removed in vacuo to give the title compound A5 as a yellow oil (680 mg, 98%); LCMS-A: rt 6.793 min; m/z 609 [M−H]−.

1. customThe volatiles were removed under reduced pressure
2. additionAqueous HCl (2 M, 50 mL) was added cautiously
3. customthe layers were separated
4. extractionThe aqueous phase was extracted with EtOAc (2×50 mL)
5. washthe combined organics were washed with brine
6. dry with materialdried over MgSO4
7. customThe solvent was removed in vacuo