Cesium carbonate → 1-(2-(2-(5-Chloro-2-(pyrimidin-5-ylamino)pyrimidin-4-yl)ethyl)phenyl)cyclopropanecarboxamide

Participants

Reaction Steps

A suspension of 1-(2-(2-(2,5-dichloropyrimidin-4-yl)ethyl)phenyl)cyclopropanecarboxamide A14 (0.100 g, 0.297 mmol), Cs2CO3 (0.291 g, 0.892 mmol) and 5-aminopyrimidine (56.6 mg, 0.595 mmol) in 1,4-dioxane (3 mL) was sonicated for 10 minutes. Xantphos (6.9 mg, 12 μmol) and Pd(II) acetate (1.3 mg, 5.9 μmol) were added and the reaction was irradiated in the microwave at 120° C. for 20 minutes. The resulting mixture was adsorbed onto silica gel and purified by column chromatography (Biotage Isolera, 40 g SiO2 cartridge, 0-100% EtOAc in petroleum benzine 40-60° C. then 0-40% MeOH in EtOAc) to give a solid which was suspended in 0.5 M aqueous citric acid (50 mL) and sonicated for 10 minutes. The precipitate was collected by filtration and the filter cake was washed with 2 M aqueous NaOH (100 mL), cyclohexane (100 mL) and air dried to give the title compound 12 as a yellow solid (25 mg, 21%). LCMS-B: rt 4.89 min; m/z 395.0 [M+H]+.

Provenance & Evidence