p-Toluenesulfonic acid → HCID 73296871, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 1-(2-(2-(2,5-dichloropyrimidin-4-yl)ethyl)phenyl)cyclopropanecarboxamide A14 (0.080 g, 0.24 mmol) in 1,4-dioxane (1.0 mL) containing aniline (0.043 mL, 0.48 mmol) and p-toluenesulfonic acid (4.5 mg, 0.024 mmol) was heated under microwave irradiation at 120° C. for 4 hours. The reaction mixture was adsorbed onto silica gel and purified by silica column chromatography (Combiflash Rf, 12 g SiO2 Cartridge, 20-50% EtOAc in cyclohexane) to give the title product 23 as a light yellow foam (0.044 g, 46%). LCMS-B: rt 7.718 min; m/z 393 [M+H]+.

Provenance & Evidence