Cesium carbonate → HCID 73297043, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 1-(2-(2-(2,5-dichloropyrimidin-4-yl)ethyl)phenyl)cyclopropanecarboxamide A14 (0.300 g, 0.892 mmol) in THF (2.5 mL) containing 5-amino-2-pyridinecarbonitrile (0.213 g, 1.78 mmol), Cs2CO3 (0.872 g, 2.67 mmol), Xantphos (0.021 g, 0.036 mmol) and palladium (II) acetate (4 mg, 0.018 mmol) was heated under microwave irradiation for 30 minutes at 120° C. The reaction mixture was adsorbed onto silica gel and purified by silica column chromatography (Combiflash Rf, 12 g SiO2 Cartridge, 0-10% MeOH in DCM) to give the title compound 31 as a cream solid (0.262 g, 70%). LCMS-B: rt 7.13 min; m/z 419 [M+H]+.

Provenance & Evidence