Cesium carbonate → HCID 73297044, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 1-(2-(2-(2,5-dichloropyrimidin-4-yl)ethyl)phenyl)cyclopropanecarboxamide A14 (0.200 g, 0.595 mmol) in 1,4-dioxane (2.0 mL) containing 1-(5-aminopyridin-2-yl)ethanone (0.121 g, 0.892 mmol), Cs2CO3 (0.581 g, 1.78 mmol), Xantphos (0.014 g, 0.024 mmol) and palladium (II) acetate (2.67 mg, 0.012 mmol) was heated under microwave irradiation for 30 minutes at 120° C. The reaction mixture was adsorbed onto silica gel and purified by silica column chromatography (Combiflash Rf, 4 g SiO2 Cartridge, 0-10% MeOH in DCM) to give title compound 32 as a light cream solid (0.183 g, 70%). LCMS-B: rt 6.98 min; m/z 437 [M+H]+.

Provenance & Evidence