tert-Butanol → HCID 10824050, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-(2-bromophenyl)-2-methylpropanenitrile A33 (0.377 g, 1.68 mmol), NaOH (0.135 g, 3.37 mmol) and t-BuOH (4 mL) was stirred in a sealed vessel at 100° C. for 40 hours. The reaction mixture was cooled, diluted with DCM and filtered through Celite. The filtrate solvent was removed in vacuo and the residue was purified by column chromatography (Biotage Isolera, 24 g SiO2 cartridge, 0-100% EtOAc in petroleum benzine 40-60° C.) to give the title compound A34 as a colourless oil (0.192 g, 48%). LCMS-D: rt 3.06 min; m/z 242/244 [M+H]+.

Provenance & Evidence