p-Toluenesulfonic acid monohydrate → HCID 73294786, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-(2-(2-(2,5-dichloropyrimidin-4-yl)ethyl)phenyl)-2-methylpropanamide A38 (0.042 g, 0.12 mmol), 1-methyl-1H-pyrazol-4-amine (0.022 g, 0.23 mmol), and p-toluenesulfonic acid monohydrate (0.002 g, 0.012 mmol) in 1,4-dioxane (4.0 mL) was heated in the microwave at 120° C. for 3 hours. After cooling, the volatiles were removed in vacuo and the residue was adsorbed onto silica. Purification by column chromatography (Biotage Isolera, 12 g SiO2, 0-5% MeOH in DCM) gave the title compound 45 as an off-white solid (0.009 g, 18%). LCMS-D: rt 3.29 min; m/z 399 [M+H]+.

Provenance & Evidence