反应详情

A mixture of TFA (0.5 mL) and tert-butyl 4-(4-((4-(2-(1-carbamoylcyclobutyl)phenethyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)phenyl)piperidine-1-carboxylate A57 (6.0 mg, 9.6 μL) in DCM (5 mL) was stirred at room temperature overnight. The volatiles were removed in vacuo before 2 M aq. NaOH (5 mL) was added to form a precipitate. The solid was collected by filtration and washed with cyclohexane (10 mL) to give the title compound 52 as a tan solid (1.5 mg, 30%). LCMS-A: rt 4.994 min; m/z 524.3 [M+H]+.

1. customThe volatiles were removed in vacuo before 2 M aq. NaOH (5 mL)
2. additionwas added
3. customto form a precipitate
4. filtrationThe solid was collected by filtration
5. washwashed with cyclohexane (10 mL)