HCID 86712347, compound → HCID 86712346, compound

Participants

Reaction Steps

A mixture of tert-butyl 4-(4-((4-((2-(1-carbamoylcyclopropyl)phenyl)ethynyl)-5-(trifluoromethyl)pyrimidin-2-yl)amino)-1H-pyrazol-1-yl)piperidine-1-carboxylate A76 (0.405 g, 0.680 mmol) and 10% Pd/C (wetted with ca. 53% water, 0.200 g) in EtOAc (30 mL) and MeOH (15 mL) was stirred under an atmosphere of H2 at room temperature for 16 hours. The mixture was filtered through a plug of Celite and the filtrate was concentrated in vacuo. Purification by column chromatography (Biotage Isolera, 40 g SiO2 cartridge, 0-10% MeOH in DCM) gave a yellow oil which was further purified by column chromatography (Biotage Isolera, 40 g SiO2 cartridge, 10-90% EtOAc in petroleum benzine 40-60° C.) to give the title compound A77 as a yellow solid (0.213 g, 52%). LCMS-D: rt 3.62 min; m/z 600 [M+H]+.

Provenance & Evidence