反应详情

A 500-mL bottle was purged with nitrogen and charged with tert-butyl 4-(6-nitropyridin-3-yl)piperazine-1-carboxylate 101g (3.1 g, 10 mmol), 10% palladium on carbon (50% wet, 1.0 g) and ethanol (100 mL). It was evacuated, charged with hydrogen gas, and stirred for 16 h at room temperature. The hydrogen was then evacuated and nitrogen was charged into the bottle. The catalyst was removed by filtration through a pad of CELITE® and the filtrate concentrated under reduced pressure to afford 101h (2.7 g, 97%). MS: [M+H]+ 279

1. customA 500-mL bottle was purged with nitrogen
2. customIt was evacuated
3. additioncharged with hydrogen gas
4. customThe hydrogen was then evacuated
5. additionnitrogen was charged into the bottle
6. customThe catalyst was removed by filtration through a pad of CELITE®
7. concentrationthe filtrate concentrated under reduced pressure