反应详情

A mixture of 101i (3.6 g, 7.8 mmol) and 4.0 M HCl/dioxane (10 mL) was stirred for 5 h at room temperature. It was then concentrated at reduced pressure. The residue was basified with aqueous 1.0M NaOH and extracted with methylene chloride. The combined organic layers were washed with water and concentrated under reduced pressure to give 101j (2.46 g, 87%). MS: [M+H]+ 364.

1. concentrationIt was then concentrated at reduced pressure
2. extractionextracted with methylene chloride
3. washThe combined organic layers were washed with water
4. concentrationconcentrated under reduced pressure