HuagongsheHuagongshe Chemistry Print Report · For research reference only
Oxalyl chloride → 2-Chloro-5-((2,2,2-trifluoroacetamido)methyl)benzoyl isocyanate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 2-Chloro-5-((2,2,2-trifluoroacetamido)methyl)benzamide | HCID 90019195 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Product | 2-Chloro-5-((2,2,2-trifluoroacetamido)methyl)benzoyl isocyanate | HCID 90019286 | 91.3% |
Reaction Steps
The title compound was prepared according to the procedure described in step-2 of Intermediate-8 by using 2-chloro-5-((2,2,2-trifluoroacetamido)methyl)benzamide (0.700 g, 2.5 mmol), oxalyl chloride (0.3 mL, 3.0 mmol) and EDC (30 mL) to afford 0.700 g of the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09439890B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-13e5ea97421248719513366fa0a7956b |
| Source note | uspto-grants-2016_09 |