HuagongsheHuagongshe Chemistry Print Report · For research reference only
tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate → (3S)-tert-Butyl 4-(6-Aminopyridin-3-yl)-3-methylpiperazine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | tert-Butyl 4-(6-aminopyridin-3-yl)piperazine-1-carboxylate | HCID 11737525 | — |
| Reactant | tert-butyl (3S)-3-methyl-4-(6-nitropyridin-3-yl)piperazine-1-carboxylate | HCID 86683728 | — |
| Product | (3S)-tert-Butyl 4-(6-Aminopyridin-3-yl)-3-methylpiperazine-1-carboxylate | HCID 86683730 | 93.1% |
Reaction Steps
Following the procedure described for compound 101h and starting with (3S)-tert-butyl 3-methyl-4-(6-nitropyridin-3-yl)piperazine-1-carboxylate 191e (5.8 g, 18 mmol) afforded 191f as a brown solid (4.9 g, 93%). MS-ESI: [M+H]+ 293
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09238655B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-34bcc6092a1a42f2a0d20bd2ceb5356b |
| Source note | uspto-grants-2016_01 |