Dimethyl Sulfoxide → HCID 58149520, compound

Participants

Reaction Steps

Under an atmosphere of argon, 50 ml of dimethyl sulphoxide were slowly added dropwise to 8.06 g (37 mmol) of trimethylsulphoxonium iodide and 1.47 g of sodium hydride (60%, 37 mmol). The reaction mixture was then stirred at room temperature for 15 min, and 5.00 g (33 mmol) of 2-methyl-1-(5-pyrimidinyl)-1-propanone, dissolved in 10 ml of tetrahydrofuran, were added. The reaction mixture was stirred at 50° C. for 90 min. The reaction mixture was then concentrated under reduced pressure, and saturated aqueous sodium chloride solution and ethyl acetate were added to the residue. The organic phase was separated off, dried over sodium sulphate, filtered and concentrated. This gave 1.36 g (25%) of the desired product, which was reacted without further purification.

Provenance & Evidence