Water → HCID 67818640, compound

Participants

Reaction Steps

A mixture of 4.4 g (25.0 mmol) of 4-trifluoromethoxyphenol and 15.5 g (112.5 mmol) of potassium carbonate in 37.5 ml of dry dimethyl sulphoxide was stirred at room temperature for 2 h. The reaction mixture was subsequently warmed to 60° C., and 25.7 g (112.5 mmol) of 2-bromo-2-methyl-1-(pyrimidin-5-yl)propan-1-one, dissolved in 12.5 ml of dimethyl sulphoxide, were added. After the addition had ended, the reaction mixture was stirred overnight. The reaction mixture was poured into 250 ml of water and extracted with 250 ml of ethyl acetate. The organic phase was separated off and then washed with saturated aqueous sodium chloride solution, dried over sodium sulphate, filtered and concentrated. The crude product was then purified by column chromatography. This gave 1.24 g (14%) of the desired product.

Provenance & Evidence