Potassium Carbonate → HCID 67813216, compound

Participants

Reaction Steps

With stirring and at room temperature, a solution of 5.5 g (31 mmol) of 1-bromo-3,3-dimethylbutan-2-one in 50 ml of acetonitrile was slowly added dropwise to a mixture of 5.5 g (31 mmol) of 4-trifluoromethoxyphenol and 4.27 g (31 mmol) of potassium carbonate in 100 ml of acetonitrile. After the addition had ended, the reaction mixture was stirred at reflux temperature overnight. The solid was filtered off and the filtrate was concentrated. The residue was taken up in 50 ml of ethyl acetate and the organic phase was washed with ice-cold 1M aqueous sodium hydroxide solution and water. The organic phase was separated off, dried over sodium sulphate, filtered and concentrated. The crude product was then purified by column chromatography. This gave 2.22 g (26%) of the desired product.

Provenance & Evidence