Pyrrole → HCID 67255453, compound

Participants

Reaction Steps

(cis, trans mixture)-2-(4-chlorobenzyl)-8,8-dimethyl-1-[1,2,4]triazole-1-ylmethyl7,9-dioxaspiro[4,5]decane-1-ol (azole derivative (V′), R6═CH3, R7═CH3, Xm=4-Cl, A=N) (359 mg) was dissolved in a 10% hydrogen chloride methanol solution, and was stirred at a room temperature for 23 hours. After the reaction, a solvent was distilled off, and water was added to a residue. A 2 mol/L sodium hydroxide aqueous solution was added to this suspension, and the resultant mixture was stirred at a room temperature for 15 minutes. The mixture was filtered to obtain a crystal, and the crystal was dried in vacuum to obtain 271.1 mg of (1SR,5RS)-5-(4-chlorobenzyl)-2,2-bishydroxymethyl-1-[1,2,4]triazole-1-ylmethylcyclopentanol(azole derivative (IV′), Xm=4-Cl, A=N).

Provenance & Evidence