HCID 131734559, compound → HCID 22872766, compound

Participants

Reaction Conditions

Reaction Steps

A warmed (50° C.) stirred suspension of magnesium bis-lysinate monohydrate (1.844 g, 5.0 mmol) in methanol (10 mL) under nitrogen was treated with a solution of EPA (3.63 g, 12 mmol) in methanol (10 mL) containing alpha-D-tocopherol (100 mg) dissolved in ethyl acetate (0.5 mL), stirred for 20 min, then the mixture was concentrated in vacuo and suspended in acetonitrile (50 mL). The suspension was stirred for 3 h, filtered, washed with acetonitrile, collected and dried in vacuo to afford 4.78 g (100%) of magnesium lysinate bis EPA as a white solid.

Provenance & Evidence