HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 5-(Aminomethyl)-2-chlorobenzoic acid hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 2-Chloro-5-[(trifluoroacetamido)methyl]benzoic acid | HCID 58483277 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 5-(Aminomethyl)-2-chlorobenzoic acid hydrochloride | HCID 67116365 | — |
Reaction Steps
To a solution of 2-chloro-5-((2,2,2-trifluoroacetamido)methyl)benzoic acid (step-1 of Intermediate-26, 10.0 g, 35.50 mmol) in methanol (100 mL) was added conc. HCl (10 mL). The reaction mixture was refluxed for 18 h. The reaction mixture was concentrated and crude reaction mixture was used for next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09439890B2 |
| Source dataset | uspto-grants-2016_09 |
| ORD ID | ord-7f0982d99a094d779f4e46ac93440b8e |
| Source note | uspto-grants-2016_09 |