Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | HCID 86703333 | HCID 86703333 | — |
| Catalyst | HCID 178418390 | HCID 178418390 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 86703332 | HCID 86703332 | 76.6% |
Reaction Steps
As presented in the following reaction formula, a mixture of (E)-3-(3-acetamido-6-chloro-2-fluorophenyl)acrylic acid (15 g, 0.058 mol), palladium carbon (Pd/C; 1.5 g, 5.8 mmol), methanol (100 mL) and triethylamine (6.4 g, 0.06 mol) was stirred under 1 atm (H2) at 50° C. overnight. The mixture was filtered and concentrated to give 3-(3-acetamido-2-fluorophenyl)propanoic acid (10 g, yield: 73%) as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09242928B2 |
|---|
| Source dataset | uspto-grants-2016_01 |
|---|
| ORD ID | ord-b1f50580ceac42cca0a1c1a30df1b13e |
|---|
| Source note | uspto-grants-2016_01 |
|---|
