Cesium carbonate → HCID 86703336, compound

Participants

Reaction Steps

As presented in the following reaction formula, N,N-diethyl-2-iodoacetamide (723 mg, 3 mmol) was added dropwise at room temperature to a mixture of 5-(benzylamino)-4-fluoro-2,3-dihydro-1H-inden-1-one (370 mg, 1.5 mmol) and cesium carbonate (Cs2CO3: 940 mg, 3 mmol) in acetonitrile (CH3CN; 20 mL). Then, the mixture was refluxed for 48 hours. The mixture was filtered and the filtrate was concentrated to give a crude product, which was purified by pre-TLC (product of Merck Co., Ltd.) to give 2-(benzyl(4-fluoro-1-oxo-2,3-dihydro-1H-inden-5-yl)amino)-N,N-diethylacetamide represented by Structural Formula (2) (5 mg, yield: 1%) as a yellow solid.

Provenance & Evidence