HuagongsheHuagongshe Chemistry Print Report · For research reference only
(4-Fluoro-2-methoxyphenyl)boronic acid → 4-(4-fluoro-2-methoxyphenyl)-N-(3-nitrophenyl)pyridin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (4-Fluoro-2-methoxyphenyl)boronic acid | HCID 2782672 | — |
| Reactant | 2-Chloro-4-(4-fluoro-2-methoxyphenyl)pyridine | HCID 58432609 | — |
| Reactant | 4-iodo-N-(3-nitrophenyl)pyridine-2-amine | HCID 68287299 | — |
| Product | 4-(4-fluoro-2-methoxyphenyl)-N-(3-nitrophenyl)pyridin-2-amine | HCID 60196542 | 80.2% |
Reaction Steps
The title compound C2 was prepared from A5 (122 mg, 0.36 mmol) and (4-fluoro-2-methoxyphenyl)boronic acid (112 mg, 0.66 mmol) following the procedure reported for the intermediate A2. The residue was purified by flash chromatography on silica gel (cHex/EtOAc 100:0 to 50:50) to yield the desired product C2 as an orange solid (98 mg, 80%). MS (ES) C18H14FN3O3 requires: 339. found: 340 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09242937B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-b997eeaaad224058af08c227227aca40 |
| Source note | uspto-grants-2016_01 |