HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(Methylsulfonyl)aniline hydrochloride → 4-(2-Methoxyphenyl)-N-(3-(methylsulfonyl)phenyl)pyridin-2-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(Methylsulfonyl)aniline hydrochloride | HCID 2735179 | — |
| Reactant | 2-Chloro-4-(2-methoxyphenyl)pyridine | HCID 58432611 | — |
| Reactant | 4-(2-methoxyphenyl)-N-(3-nitrophenyl)pyridin-2-amine | HCID 60196541 | — |
| Product | 4-(2-Methoxyphenyl)-N-(3-(methylsulfonyl)phenyl)pyridin-2-amine | HCID 60197049 | — |
Reaction Steps
F1 was prepared from A1 (281 mg, 1.28 mmol) and 3-(methylsulfonyl)aniline hydrochloride (267 mg, 1.28 mmol) following the procedure reported for C1. Yield: 210 mg (46%). 1H NMR (400 MHz, d6-DMSO, 300K) δ 3.18 (s, 3H), 3.80 (s, 3H), 7.02-7.08 (m, 2H), 7.12-7.18 (m, 2H), 7.35-7.45 (m, 2H), 7.50-7.53 (m, 1H), 7.53-7.62 (m, 1H), 7.92 (d, J=8.0 Hz, 1H), 8.12-8.19 (m, 2H), 10.05 (bs, 1H). MS (ES) C19H18N2O3S requires: 354. found: 355 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09242937B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-30532291b7f243e48e4ae8e33168c8e0 |
| Source note | uspto-grants-2016_01 |