Methanol → AGN-PC-008D8H

Temperature

5 °C

Next, a mixed solution of bis(3-chloro-2-hydroxypropyl)disulfide described above and 250 g of methanol was dripped into a reaction vessel containing a mixed solvent consisting of 500 g of toluene and 240 g of 47% aqueous solution of sodium hydroxide with the temperature of the solution in the reaction vessel being maintained at 0 to 10° C. At the point of the completion, no scum-like insoluble matter was generated. 100 g of toluene was added to carry out extraction, the aqueous layer was removed, and the organic layer was washed with 180 g of water three times. After that, no scum-like insoluble matter was generated. After that, the solvent was distilled away, thereby obtaining 171 g of bis(β-epoxypropyl)disulfide.

1. customwas dripped into a reaction vessel
2. additioncontaining a mixed solvent
3. extractionextraction
4. customthe aqueous layer was removed
5. washthe organic layer was washed with 180 g of water three times
6. distillationAfter that, the solvent was distilled away

ORD record

ord-da3eba83bc83494aaff3409b0343bcb1

Source dataset

uspto-grants-2016_01

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09242947B2