HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonium Chloride → 5-(5-Bromo-2-fluorophenyl)-5,6-dihydro-5-methyl-2H-1,4-oxazin-3-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonium Chloride | HCID 25517 | — |
| Reactant | Oxonium, trimethyl-, tetrafluoroborate(1-) (1:1) | HCID 2735153 | — |
| Reactant | 5-(5-Bromo-2-fluorophenyl)-5-methylmorpholin-3-one | HCID 58155262 | — |
| Product | 5-(5-Bromo-2-fluorophenyl)-5,6-dihydro-5-methyl-2H-1,4-oxazin-3-amine | HCID 66931571 | — |
Reaction Steps
In analogy to step a) in the synthesis of building block D, the treatment of (RS)-5-(5-bromo-2-fluoro-phenyl)-5-methyl-morpholin-3-one with trimethyloxonium tetrafluoroborate followed by the nucleophilic substitution with ammonium chloride yielded the title compound; its hydrochloride was obtained as a white solid. Mass (calculated) C11H12BrFN2O [287.13]; (found) [M+H]+=287, [M+2+H]+=289.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09242943B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-82bb137a15ef4aee82d1a992f866dd19 |
| Source note | uspto-grants-2016_01 |