HuagongsheHuagongshe Chemistry Print Report · For research reference only
2,2,2-Trifluoroethyl Methanesulfonate → 8-Nitro-3-(2,2,2-trifluoro-ethoxy)-quinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2,2,2-Trifluoroethyl Methanesulfonate | HCID 556565 | — |
| Reactant | 8-Nitro-3-quinolinol | HCID 54366974 | — |
| Product | 8-Nitro-3-(2,2,2-trifluoro-ethoxy)-quinoline | HCID 68107900 | 18% |
Reaction Steps
In a manner analogous to that described in Example 30 a) the alkylation of the 8-nitro-quinolin-3-ol (CAS25369-37-3) with methanesulfonic acid 2,2,2-trifluoro-ethyl ester yielded the title compound as a yellow solid (yield 18%); (calculated) C11H7F3N2O3 [272.2]; (found) [M+H]+=273.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09242943B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-9b0d936f8a5d4ee5861144e935fe608f |
| Source note | uspto-grants-2016_01 |