6-Chloro-1-methyl-1H-indazol-3-amine → HCID 57520208, compound

HRID 593354Notes

Reaction equation

HRID 593354 reaction equation
ClC1C=C2C(C(N)=NN2C)=CC=1.[NH2:13][C:14]1[CH2:19][O:18][CH2:17][C@:16]([C:21]2[CH:22]=[C:23]([NH:28][C:29]3[C:37]4[C:32](=[CH:33][C:34]([Cl:38])=[CH:35][CH:36]=4)[N:31]([CH3:39])[N:30]=3)[CH:24]=[CH:25][C:26]=2[F:27])([CH3:20])[N:15]=1>>[Cl:38][C:34]1[CH:33]=[C:32]2[C:37]([C:29]([NH:28][C:23]3[CH:24]=[CH:25][C:26]([F:27])=[C:21]([C@@:16]4([CH3:20])[CH2:17][O:18][CH2:19][C:14]([NH2:13])=[N:15]4)[CH:22]=3)=[N:30][N:31]2[CH3:39])=[CH:36][CH:35]=1

Participants

3

Reactant 2

HCID 288753136-Chloro-1-methyl-1H-indazol-3-amineHCID 68107604HCID 68107604, compound

Product 1

HCID 57520208HCID 57520208, compound

Procedure

With 6-chloro-1-methyl-1H-indazol-3-ylamine (CAS1031927-22-6) the [3-((R)-5-amino-3-methyl-3,6-dihydro-2H-[1,4]oxazin-3-yl)-4-fluoro-phenyl]-(6-chloro-1-methyl-1H-indazol-3-yl)-amine as a light grey solid; (calculated) C19H19ClFN5O [387.84]; (found) [M+H]+=388.

Sources & evidence

ORD record
ord-030241e8d5374ca4904f53432973b2d0
Source dataset
uspto-grants-2016_01
Patent number
US09242943B2

Reaction notes

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