Methyl iodide → 8-Nitro-3-methoxy-quinoline

HRID 593355Notes

Reaction equation

HRID 593355 reaction equation
[N+:1]([C:4]1[CH:5]=[CH:6][CH:7]=[C:8]2[C:13]=1[N:12]=[CH:11][C:10]([OH:14])=[CH:9]2)([O-:3])=[O:2].I[CH3:16]>>[N+:1]([C:4]1[CH:5]=[CH:6][CH:7]=[C:8]2[C:13]=1[N:12]=[CH:11][C:10]([O:14][CH3:16])=[CH:9]2)([O-:3])=[O:2]

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 543669748-Nitro-3-quinolinol

Product 1

HCID 681072298-Nitro-3-methoxy-quinolineYield 26%

Procedure

In a manner analogous to that described in Example 30 a) the alkylation of the 8-nitro-quinolin-3-ol (CAS25369-37-3) with iodomethane yielded the title compound as a yellow solid (yield 26%).

Sources & evidence

ORD record
ord-fca6f4f8a7894f84ada89db16989a10f
Source dataset
uspto-grants-2016_01
Patent number
US09242943B2

Reaction notes

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