Ammonium Chloride → HCID 61101071, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 3-iodobenzaldehyde (10 g) in tetrahydrofuran (50 mL) at 30° C. is added a 0.43M solution of p-tolylmagnesium bromide in tetrahydrofuran. After stirring at 50° C. for 1 hour, the reaction mixture is hydrolyzed with a saturated aqueous solution of ammonium chloride and extracted ethyl acetate. Pooled organic extracts are washed with brine, dried over magnesium sulfate and concentrated. The residue is purified by column chromatography over silica gel (gradient heptane/ethyl acetate 95/5 to 90/10) to yield (3-iodophenyl)-p-tolylmethanol.

Provenance & Evidence