HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 59341Generated: October 29, 2026
Oxalyl chloride → 6-Chloro-2-fluoro-3-(pivalamidomethyl)benzoyl isocyanate
https://huagongshe.com/reaction/59341
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Oxalyl chloride | HCID 65578 | — |
| Reactant | 6-Chloro-2-fluoro-3-(pivalamidomethyl)benzamide | HCID 90019502 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Product | 6-Chloro-2-fluoro-3-(pivalamidomethyl)benzoyl isocyanate | HCID 90019745 | 307.5% |
Reaction Steps
To a solution of 6-chloro-2-fluoro-3-(pivalamidomethyl)benzamide (0.300 g, 1.04 mmol) in EDC (10 mL) was added oxalyl chloride (0.11 mL, 1.25 mmol). The reaction mass was heated at 60-70° C. for 4-5 h. Excess of solvent was removed under vacuum to afford 1.0 g of desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US09439890B2 |
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| Source dataset | uspto-grants-2016_09 |
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| ORD ID | ord-a8c9d7c9b3314fe6945cfa1466867455 |
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| Source note | uspto-grants-2016_09 |
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